SOLUTION for the "Non Active LOAD" or broken saves in the MAIN MENU: This occurs simply because your save file path has been changed due to Windows Update most likely or other unknown reasons. What you need to do is simply navigate to: C:\Users\user_name\Documents\My Games\Fallout 4 and look for a file called "Fallout4Custom.ini". Edit line
Now, one good way to delete the game and all mod stuff is use the control panel 'uninstall' a program (Fallout 4) to get rid of all even the mods. Also delete all your saves. They will be in User/Documents/My Games/Fallout 4/Saves. Just delete the files that show up under the Saves and nothing else.
dLJw.